My impression of mixi2 is that they've done a lot of research on Misskey.
The elements that are considered to be advantageous to most people compared to Misskey are:
- App available (official only, no room for hesitation)
- Closed
- Simple and excellent UI
- Lightweight app
- Strict rules on prohibited activities aimed at the general public
- Managed by a long-established SNS company with strong capital and profitability